โ† All from PawCorner
๐Ÿฉบ Vet ReviewedBy Reviewer Dr. Ashim Sarkar, BVSc & AHยท Last reviewed Aug 4, 2026

Addison's Disease in Dogs: Symptoms and Warning Signs

Quick Answer

Addison's disease in dogs, or hypoadrenocorticism, is a hormone disorder where the adrenal glands do not make enough cortisol and aldosterone. Signs are vague and come and go: low energy, poor appetite, vomiting, diarrhoea, weight loss, and increased thirst. It can suddenly turn into a life-threatening crisis with collapse, so any unexplained collapse needs an emergency vet at once.

Key Takeaways

  • Addison's disease (hypoadrenocorticism) is a shortage of the adrenal hormones cortisol and aldosterone, which the body needs to handle stress and to balance salt and water.
  • It is nicknamed the great pretender because the signs are vague and often wax and wane: low energy, poor appetite, vomiting, diarrhoea, weight loss, shivering, and drinking more than usual.
  • An Addisonian crisis is a true emergency. Sudden collapse, severe weakness, or a dog that cannot get up, often after a stressful event, needs an emergency vet right away.
  • Addison's cannot be confirmed by symptoms alone. A vet diagnoses it with blood tests, including an ACTH stimulation test, that check hormone levels and salt-potassium balance.
  • With lifelong hormone replacement most Addison's dogs live full, normal lives, so the goal is to catch it and get the diagnosis before a crisis happens.
A dog lying down looking tired, low in energy, and unwell

Photo via Unsplash

Reviewed by Dr. Ashim Sarkar, BVSc & AH, veterinarian with 2.5 years of hands-on experience in small animal practice. This content is for informational purposes only and does not constitute veterinary advice. Always consult a licensed veterinarian for your pet's health concerns.

What is Addison's disease in dogs?

Addison's disease, known to vets as hypoadrenocorticism, is a hormone disorder where a dog's adrenal glands stop making enough of two vital hormones. The adrenal glands are two small glands that sit near the kidneys. They produce cortisol, which helps the body handle stress and keep blood sugar steady, and aldosterone, which balances salt, potassium, and water. In Addison's disease both run low, so the dog cannot cope with everyday stress the way a healthy dog does.

The tricky part is that the early signs are quiet and easy to miss. A dog might just seem a bit tired, go off its food for a day or two, have a bout of vomiting, then appear to bounce back. Because of this on-and-off pattern, vets often call Addison's the great pretender. According to the MSD Veterinary Manual, the illness can range from mild and vague all the way to a sudden collapse, so it deserves to be taken seriously even when the signs seem small.

Addison's cannot be confirmed by symptoms alone. It needs a vet and blood tests to diagnose. The good news, which is worth holding on to, is that once it is diagnosed and treated with hormone replacement, most dogs go on to live full, normal lives.

Not sure whether what you are seeing needs a vet? You can check your dog's symptoms free in the Omelo app in about 30 seconds and get a plain read on how urgent it looks. In India, you can also book a 15-minute video consultation with a licensed vet for โ‚น349 at vet.beomelo.com if you would like a professional to look at what you are describing.

Why Addison's is called the great pretender

Most diseases have a signature look. Addison's does not. The hormones it affects touch the gut, the energy system, the heart, and the body's whole stress response, so the signs it produces are the same vague signs that dozens of other problems cause. A dog with Addison's can look like a dog with a simple upset stomach, a fussy eater, or a pet that is just a little low.

The clue is the pattern rather than any single sign. Addison's often waxes and wanes. The dog seems unwell, then recovers, then dips again, and the dips frequently follow something stressful. A boarding stay, a long car journey, a house move, a thunderstorm season, or even a change in routine can tip a dog with borderline adrenal function into a flare. If your dog has repeated, unexplained bouts of feeling off that seem to line up with stressful events, that is worth mentioning to your vet by name, because it can point them toward testing for Addison's sooner.

Symptoms of Addison's disease to watch for

The symptoms of Addison's disease are broad and often mild between flares. Watch for:
  • Low energy and lethargy, a dog that is flatter than usual and less keen to play or walk.
  • Poor appetite or going off food completely.
  • Vomiting and diarrhoea, sometimes on and off over weeks.
  • Gradual weight loss.
  • Shivering, trembling, or muscle weakness.
  • Drinking more water and urinating more than usual.
  • A generally unwell dog whose signs improve and then return.

You will rarely see all of these at once. It is the combination of vague gut upset, low energy, and a waxing-and-waning course, especially in a young to middle-aged dog, that should put Addison's on the list. Because these signs overlap with so many other conditions, from kidney disease to a simple infection, only blood tests can sort out what is really going on.

Addisonian crisis: the warning signs that mean emergency

Addison's has a dangerous side that every owner should know about. An Addisonian crisis happens when cortisol drops too low and potassium climbs too high, and the dog goes into shock. This is a true, life-threatening emergency and it can come on fast, often after a stressful trigger.

Get to your nearest emergency vet immediately, at any hour, if your dog shows:

  • Sudden collapse or fainting.
  • Severe weakness, or a dog that cannot stand or get up.
  • Repeated vomiting or diarrhoea with obvious exhaustion.
  • Cold limbs, pale gums, or a dog that feels limp and unresponsive.
  • A very slow heartbeat, or breathing that looks laboured.

Do not wait to see if it passes, and do not spend time on an app or a phone booking in this situation. A crisis needs hands-on emergency treatment with intravenous fluids and hormone support. Take your dog to the closest open clinic. If your dog has already been diagnosed with Addison's, tell the emergency team straight away, because it changes how they treat the collapse.

What causes Addison's disease in dogs

In most dogs, Addison's happens because the body's own immune system gradually damages the adrenal glands until they can no longer make enough hormones. This immune-mediated destruction is the usual cause, and it is not something an owner can see coming or prevent. Less often, damage to the pituitary gland in the brain, which signals the adrenals, leads to a form of the disease.

Get a 3-question triage and a vet-reviewed action plan.

Free. 30 seconds. No credit card. iOS and Android.

There is also an important cause that owners can influence. Dogs on long-term steroids, or dogs being treated for Cushing's disease with medicines such as trilostane, can develop Addison-like signs if the drug is stopped abruptly or the dose is too high. This is exactly why you should never start or stop steroid medication on your own. Any change to these drugs should be planned with your vet and tapered, not halted overnight.

Which dogs are more at risk

Addison's is most often diagnosed in young to middle-aged dogs, and female dogs are affected a little more often than males, although any dog of any age or sex can develop it. Certain breeds carry a higher genetic risk, including the Standard Poodle, Portuguese Water Dog, Bearded Collie, Nova Scotia Duck Tolling Retriever, West Highland White Terrier, and Wheaten Terrier. Great Danes are also mentioned in some breed lists.

If you own one of these breeds, you do not need to worry constantly, but it is worth knowing the signs so you can act early. Mixed-breed dogs get Addison's too, so breed is only one piece of the picture, not a rule.

How a vet diagnoses and treats Addison's

A vet works out Addison's with a physical exam and blood tests. Routine bloodwork often shows a telltale imbalance, a low sodium level alongside a high potassium level, which gives a low sodium to potassium ratio. The confirming test is an ACTH stimulation test. It measures how the adrenal glands respond when they are prompted, and a poor response confirms the diagnosis. Your vet may also run tests to rule out kidney disease and other conditions that look similar.

Treatment is lifelong hormone replacement, and it works well. Most dogs are managed with two things together:

  • A mineralocorticoid to replace aldosterone, commonly a DOCP injection given every few weeks, or a daily tablet such as fludrocortisone.
  • A low daily dose of a glucocorticoid, usually prednisolone, to replace cortisol, with the dose increased during stressful times like travel, illness, or boarding on your vet's instructions.

Your vet will fine-tune the doses with follow-up blood tests over the first weeks and months, then at regular rechecks. Please do not adjust or stop these medicines on your own. Getting the balance right is what keeps your dog stable and out of a crisis. Many owners are relieved to find that once treatment is settled, their dog is back to normal energy, appetite, and spirits.

Living well with a dog who has Addison's

Addison's itself cannot really be prevented, since the common cause is the immune system quietly damaging the adrenal glands. What you can prevent is a dangerous crisis, and that comes down to two things: getting the diagnosis early, and managing the disease carefully once it is known.

Practical habits that help:

  • Give the medication exactly as prescribed and never skip or double doses.
  • Ask your vet ahead of any stressful event, such as boarding, surgery, travel, or festival fireworks season, whether your dog needs an extra glucocorticoid dose.
  • Keep up regular rechecks and blood tests so the dose stays right.
  • Carry a note or tag saying your dog has Addison's, so any vet who sees them in an emergency knows immediately.
  • Learn the crisis red flags above and act on them without delay.

With that routine in place, an Addison's diagnosis is very manageable, and it does not shorten most dogs' lives.

Where Omelo fits, and where it does not

Omelo is a free AI symptom checker for dogs and cats. If your dog has been low in energy, off food, vomiting on and off, or losing weight, you can describe or scan the symptoms in the app and get a fast, plain read on whether this needs a vet and how soon. Because Omelo keeps a baseline for your dog, it can help you spot the waxing-and-waning pattern that makes Addison's so easy to miss, and that early nudge is exactly what this disease needs.

Omelo does not diagnose, treat, or prescribe, and it cannot confirm Addison's disease. Only a vet with blood tests, including an ACTH stimulation test, can do that. Think of the app as the step that helps you decide to go to the vet and how urgently, not a replacement for the clinic. And if your dog collapses or is severely weak, skip the app entirely and go straight to an emergency vet.

In India, if you would like a licensed vet to weigh in before you plan a clinic visit, you can book a 15-minute video consultation for โ‚น349 at vet.beomelo.com. A vet can talk through the pattern you are seeing and help you decide on next steps, including the in-person testing that Addison's needs to confirm.

Related reading

- Free dog symptom checker - Cushing's disease in dogs and hind leg weakness - Diabetes in dogs: early signs - Kidney disease in dogs: early signs - Dog lethargy: causes and when to worry - Is my dog sick? Signs to watch and when to see a vet

Addison's Disease in Dogs: Frequently Asked Questions

What is Addison's disease in dogs?

Addison's disease, also called hypoadrenocorticism, is a condition where a dog's adrenal glands do not make enough of two important hormones, cortisol and aldosterone. Cortisol helps the body cope with stress and keeps blood sugar steady, and aldosterone controls the balance of salt, potassium, and water. When these run low, the dog struggles to handle everyday stress, and the signs can range from vague tiredness to a sudden, life-threatening collapse.

What are the early symptoms of Addison's disease in dogs?

Early signs are subtle and tend to come and go, which is why Addison's is often missed at first. Owners notice low energy, a dog going off its food, occasional vomiting or diarrhoea, gradual weight loss, shivering or muscle weakness, and sometimes drinking and urinating more. A common pattern is a dog that seems unwell, appears to recover, then dips again, often after something stressful like boarding, travel, or a change at home.

Is Addison's disease in dogs an emergency?

It can be. Most of the time Addison's shows up as vague, on-and-off illness that needs a vet visit and blood tests, not a midnight dash. But it can also cause an Addisonian crisis, which is sudden collapse and shock from very low cortisol and dangerous potassium levels. If your dog collapses, is too weak to stand, or is severely unwell, that is an emergency. Go to your nearest emergency vet straight away.

How is Addison's disease diagnosed and treated in dogs?

A vet diagnoses Addison's with blood tests. Routine bloodwork often shows a low sodium to potassium ratio, and the confirming test is an ACTH stimulation test, which measures how the adrenal glands respond. Treatment is lifelong hormone replacement, usually a mineralocorticoid such as a DOCP injection plus a low daily dose of a glucocorticoid like prednisolone, with extra during stressful times. Never start or stop steroids on your own, as sudden changes can trigger a crisis.

Can a dog live a normal life with Addison's disease?

Yes. Once Addison's is diagnosed and the dog is on the right hormone replacement, most dogs live full, comfortable, normal-length lives. It does mean lifelong medication, regular vet rechecks, blood tests to fine-tune the dose, and giving extra medication during stressful events on your vet's advice. Many owners find that once the balance is right, their dog is back to being themselves.

Which dogs are more likely to get Addison's disease?

Addison's most often affects young to middle-aged dogs, and female dogs are diagnosed a little more often than males, though any dog can develop it. Some breeds carry a higher risk, including the Standard Poodle, Portuguese Water Dog, Bearded Collie, Nova Scotia Duck Tolling Retriever, West Highland White Terrier, and Wheaten Terrier. A family history in the breed line can raise the odds, but plenty of mixed-breed dogs are affected too.

References

  1. MSD Veterinary Manual: Addison Disease (Hypoadrenocorticism) in Animals
  2. MSD Veterinary Manual: The Adrenal Glands
  3. VCA Animal Hospitals: Addison's Disease in Dogs
  4. American College of Veterinary Internal Medicine (ACVIM)

Get a 3-question triage and a vet-reviewed action plan.

Free. 30 seconds. No credit card. iOS and Android.

More in Vet Reviewed

Breed-Specific Health Guides

View all breed health guides

Was this article helpful?

Dr. Ashim Sarkar, BVSc & AH

Veterinarian ยท Medical Reviewer

Reviews all clinical and triage content on Omelo. Hands-on small-animal practice experience across vomiting, dermatology, vaccinations, and emergency triage. All Omelo recommendations pass through Dr. Sarkar before publication.

Read Dr. Sarkar's full bio โ†’